A game where you build creatures from muscles, tendons, bones, blood vessels, other fluid containment and transport organs, as well as nerves and brains. Probably would look very gross. Gore-centric game.

Similarly, a game where you build robots out of Pistons, gears, Axels, fluid tanks and hoses, engines, sensors, computers and wires.

Either one of these premises is pretty amenable to a backstory where you're trying to escape-from/survive-on an alien world.