Larry Tesler, a computer scientist who created the terms "cut," "copy," and "paste," has passed away at the age of 74 (17 Feb 2020).

In 1973, Tesler took a job at the Xerox Palo Alto Research Center (PARC) where he worked until 1980. Xerox PARC is famously known for developing the mouse-driven graphical user interface and during his time at the lab Tesler worked with Tim Mott to create a word processor called Gypsy that is best known for coining the terms "cut," "copy," and "paste".

In addition to "cut," "copy," and "paste" terminologies, Tesler was also an advocate for an approach to UI design known as modeless computing. It ensures that user actions remain consistent throughout an operating system's various functions and apps. When they've opened a word processor, for instance, users now just automatically assume that hitting any of the alphanumeric keys on their keyboard will result in that character showing up on-screen at the cursor's insertion point. But there was a time when word processors could be switched between multiple modes where typing on the keyboard would either add characters to a document or alternately allow functional commands to be entered.

PM - We are going to launch registration of users in mobile phone. We are going to use blah internal framework as with it we will have same experience in mobile and desktop will be same.
Me - Shouldn't the experience be different on desktop its easy. On mobile following that many steps may seem complicated to the user.
PM - No but the experience should remain same.
Me - face palm(sees the overly complicated framework just for building 4 pages spends time finds bug in the framework fixes them and takes four months of frustration but launches it)
PM - We feel like ideally mobile and desktop should have different experience. This allows us to register faster on mobile. As we have already aligned with the blah framework team and think best path is to build it from scratch.
Me -

When I had to choose a service, I chose bitbucket. Now the other two are getting flamed. Seems like I chose right. But in the end who knows what is good and what is bad. Peaches are delicious. Winter is coming. And I definitely don't care.

Today I will talk about Android OS being stupid.

Android lets u as a user move installed apps to external storage = microSD card.

However what is stupid about it is that only a small part of the app will be moved. For example, if you have an app taking 400 MB of storage, then "moving" it will move only about 100 MB of data to microSD card, while the remaining 300 MB of data will remain on the internal storage...

In Android 11 this is still not improved. Imagine having 11 versions of OS over 11 years and never making a crucial feature work properly. Meanwhile app sizes grow ever larger

Disappointing.

I don't have any experience with cloud providers and I need to get a server for a project.
The website will be up for 3 weeks, access will probably be very uneven, the total user count is somewhat below 2000.
The site will probably be quite interactive and real-time, content may be changing every few seconds for an hour and then remain unchanged for days. I will also need either SSE or websockets for this reason.
What should I consider when selecting a cloud providers? Do you have a good one? My ideal provider would scale resources according to traffic like I've heard AWS does, but I want to hear your opinion first especially considering I know very little about how server load works.

When user interface elements unsolicitedly change their position, something unexpected might be clicked.

For example, the search engine list at the bottom of the Firefox suggestion box that appears when typing something into the URL bar ("This time, search with:"). When the number of suggestions changes, the height of the box changes, and since the search engine list is at the bottom, its position changes too. This could happen milliseconds before I wanted to click on one, which causes either searching for something I did not look for, or closing the URL bar.

It also causes an uncertainty whether the buttons will remain in place, causing delays until clicking.

The same happens on the image context menu for images on the Kiwi browser. It shows a preview thumbnail on top of the options in the context menu, but since the context menu opens before the thumbnail loads, the appearance of the thumbnail pushes the options down. If this happens few milliseconds before one is going to tap on something, it causes one to tap on the wrong place.

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Cancer Immunotherapy Market Extensive Industry Analysis, Growth Rate, Segmentation, Investment Opportunities and Top Manufacturers 2035

The global cancer immunotherapy market is on a promising trajectory, with a projected value increase from USD 134.40 billion in 2024 to USD 346.63 billion by 2035, reflecting a compound annual growth rate (CAGR) of 8.8%. This innovative therapeutic approach leverages the body’s immune system to identify and combat cancer cells, presenting a compelling alternative to traditional treatments like chemotherapy and radiation, which often come with significant side effects.

Market Growth Projections

The market is anticipated to grow significantly, reaching USD 148.73 billion in 2025 before hitting USD 346.63 billion by 2035. The rising incidence of cancer globally, projected to see around 2,041,910 new cases and approximately 618,120 deaths in the U.S. alone by 2025, is a primary driver behind this growth.

Drivers of Growth

Key factors propelling the market include the increasing prevalence of cancer and a growing demand for targeted therapies. Cancer immunotherapy offers a more precise approach, effectively directing the immune response to target cancerous cells while sparing normal cells. This specificity has made it a preferred treatment modality, especially for patients who have developed resistance to traditional therapies.

Segmentation

The cancer immunotherapy market is segmented by several criteria:

1. Type of Product: This includes immune checkpoint inhibitors, cell therapies, cancer vaccines, immunomodulators, monoclonal antibodies, and oncolytic viral therapies.
2. Application: Key applications include breast cancer, colorectal cancer, head and neck cancer, lung cancer, melanoma, ovarian cancer, prostate cancer, pancreatic cancer, and others.
3. Route of Administration: Segments include intravenous (IV), intramuscular, and oral routes. Notably, the oral administration segment currently holds the largest market share due to patient preference for self-administration.
4. Mechanism of Action: This includes immune checkpoint inhibitors, tumor antigen targeted therapy, cell signaling modulators, and immune modulators.
5. Distribution Channel: The market is divided into hospital pharmacies, retail pharmacies, and online pharmacies, with hospital pharmacies accounting for the largest share.
6. End User: The primary end users include hospitals and clinics, cancer research centers, and other entities.
7. Geographical Regions: The market is analyzed across North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America, with North America currently holding the largest share.

Challenges

Despite the promising growth, the market faces significant challenges. The high costs associated with cancer immunotherapy, stringent regulatory guidelines, and tumor heterogeneity—which can complicate treatment efficacy—pose substantial barriers. Additionally, immune-related adverse events can hinder widespread adoption.

Key Players in the Industry

The competitive landscape features numerous established and emerging players actively engaging in research and development to enhance clinical pipelines for cancer therapies. Key players include AstraZeneca, Amgen, AbbVie, Bristol-Myers Squibb, and Pfizer, among others. These companies are involved in strategic initiatives such as partnerships and collaborations to advance their therapeutic offerings.

Recent Developments

Recent advancements in the field have seen significant investments in research to enhance cancer immunotherapy. For instance, collaborations like that between The University of Pennsylvania and the Parker Institute for Cancer Immunotherapy, which renewed their alliance with a USD 125 million investment, highlight ongoing efforts to push the boundaries of cancer treatment.

Conclusion

The cancer immunotherapy market is poised for significant growth, driven by increasing cancer incidence and the demand for more effective, targeted therapies. While challenges remain, ongoing research and developments promise to enhance the effectiveness and accessibility of immunotherapy treatments, making this an exciting area of focus within the biopharmaceutical industry.

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